GenePlus Hereditary Breast & Ovarian Cancer Screening Package (26 genes)
Women who inherit harmful gene mutations can have up to 85% risk to develop breast & ovarian cancer by the age of 80.
Germline mutations in BRCA1 and BRCA2 genes have been associated with an increased risk of breast and ovarian cancer.¹ Approximately 25% of hereditary breast cancer cases are caused by BRCA1 and BRCA2 mutations,² and around 10% of all breast cancers.³ Mutations in BRCA1 and BRCA2 account for around 15% of ovarian cancers overall.4 With CarePlus Heditary Breast and Ovarian Cancer Genetic test, you can be assured that no pathogenic variant will be missed. CarePlus provides targeted and affordable BRCA1 and BRCA2 testing, and also offers an extended 26-gene panel that analyzes other relevant genes for mutations that could also increase the risk of hereditary breast and ovarian cancer, as recommended by medical guidelines.5
¹ Nature Genetics 15, 103 - 105 (1997)
² Breast Cancer Research 1999; 1(1):14–17.
³ Human Genetics 2008; 124(1):31–42.
4 Cancer 2005; 104(12):2807–16.
5 National Comprehensive Cancer Network (NCCN).
Genetic/Familial High-Risk Assessment: Breast and Ovarian.
List of genes:
- BRCA1
- BRCA2
- CHEK2
- PALB2
- BRIP1
- TP53
- PTEN
- STK11
- CDH1
- ATM
- BARD1
- MLH1
- MRE11A
- MSH2
- MSH6
- MUTYH
- NBN
- PMS1
- PMS2
- RAD50
- RAD51C
- RAD51D
- NF1
- EPCAM
- SMARCA4
- HOXB13